A pre-clinical murine model of oral implant osseointegration.
Identifieur interne : 000A88 ( Main/Exploration ); précédent : 000A87; suivant : 000A89A pre-clinical murine model of oral implant osseointegration.
Auteurs : S. Mouraret [France] ; D J Hunter ; C. Bardet ; J B Brunski ; P. Bouchard ; J A HelmsSource :
- Bone [ 1873-2763 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cicatrisation de plaie, Crête neurale (anatomopathologie), Crête neurale (imagerie diagnostique), Humains, Implants dentaires, Maxillaire (anatomopathologie), Maxillaire (imagerie diagnostique), Modèles animaux, Mésoderme (anatomopathologie), Ostéo-intégration, Ostéocytes (anatomopathologie), Radiographie, Remodelage osseux, Souris, Survie cellulaire, Tibia (anatomopathologie), Tibia (imagerie diagnostique).
- MESH :
- anatomopathologie : Crête neurale, Maxillaire, Mésoderme, Ostéocytes, Tibia.
- imagerie diagnostique : Crête neurale, Maxillaire, Tibia.
- Animaux, Cicatrisation de plaie, Humains, Implants dentaires, Modèles animaux, Ostéo-intégration, Radiographie, Remodelage osseux, Souris, Survie cellulaire.
English descriptors
- KwdEn :
- Animals, Bone Remodeling, Cell Survival, Dental Implants, Humans, Maxilla (diagnostic imaging), Maxilla (pathology), Mesoderm (pathology), Mice, Models, Animal, Neural Crest (diagnostic imaging), Neural Crest (pathology), Osseointegration, Osteocytes (pathology), Radiography, Tibia (diagnostic imaging), Tibia (pathology), Wound Healing.
- MESH :
- chemical : Dental Implants.
- diagnostic imaging : Maxilla, Neural Crest, Tibia.
- pathology : Maxilla, Mesoderm, Neural Crest, Osteocytes, Tibia.
- Animals, Bone Remodeling, Cell Survival, Humans, Mice, Models, Animal, Osseointegration, Radiography, Wound Healing.
Abstract
Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery. Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.
DOI: 10.1016/j.bone.2013.07.021
PubMed: 23886841
Affiliations:
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Le document en format XML
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Mouraret</name><affiliation wicri:level="3"><nlm:affiliation>Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D J" last="Hunter">D J Hunter</name></author><author><name sortKey="Bardet, C" sort="Bardet, C" uniqKey="Bardet C" first="C" last="Bardet">C. Bardet</name></author><author><name sortKey="Brunski, J B" sort="Brunski, J B" uniqKey="Brunski J" first="J B" last="Brunski">J B Brunski</name></author><author><name sortKey="Bouchard, P" sort="Bouchard, P" uniqKey="Bouchard P" first="P" last="Bouchard">P. Bouchard</name></author><author><name sortKey="Helms, J A" sort="Helms, J A" uniqKey="Helms J" first="J A" last="Helms">J A Helms</name></author></analytic><series><title level="j">Bone</title><idno type="eISSN">1873-2763</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Remodeling</term><term>Cell Survival</term><term>Dental Implants</term><term>Humans</term><term>Maxilla (diagnostic imaging)</term><term>Maxilla (pathology)</term><term>Mesoderm (pathology)</term><term>Mice</term><term>Models, Animal</term><term>Neural Crest (diagnostic imaging)</term><term>Neural Crest (pathology)</term><term>Osseointegration</term><term>Osteocytes (pathology)</term><term>Radiography</term><term>Tibia (diagnostic imaging)</term><term>Tibia (pathology)</term><term>Wound Healing</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cicatrisation de plaie</term><term>Crête neurale (anatomopathologie)</term><term>Crête neurale (imagerie diagnostique)</term><term>Humains</term><term>Implants dentaires</term><term>Maxillaire (anatomopathologie)</term><term>Maxillaire (imagerie diagnostique)</term><term>Modèles animaux</term><term>Mésoderme (anatomopathologie)</term><term>Ostéo-intégration</term><term>Ostéocytes (anatomopathologie)</term><term>Radiographie</term><term>Remodelage osseux</term><term>Souris</term><term>Survie cellulaire</term><term>Tibia (anatomopathologie)</term><term>Tibia (imagerie diagnostique)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Crête neurale</term><term>Maxillaire</term><term>Mésoderme</term><term>Ostéocytes</term><term>Tibia</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Maxilla</term><term>Neural Crest</term><term>Tibia</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Crête neurale</term><term>Maxillaire</term><term>Tibia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Maxilla</term><term>Mesoderm</term><term>Neural Crest</term><term>Osteocytes</term><term>Tibia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bone Remodeling</term><term>Cell Survival</term><term>Humans</term><term>Mice</term><term>Models, Animal</term><term>Osseointegration</term><term>Radiography</term><term>Wound Healing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cicatrisation de plaie</term><term>Humains</term><term>Implants dentaires</term><term>Modèles animaux</term><term>Ostéo-intégration</term><term>Radiographie</term><term>Remodelage osseux</term><term>Souris</term><term>Survie cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery. Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Bardet, C" sort="Bardet, C" uniqKey="Bardet C" first="C" last="Bardet">C. Bardet</name><name sortKey="Bouchard, P" sort="Bouchard, P" uniqKey="Bouchard P" first="P" last="Bouchard">P. Bouchard</name><name sortKey="Brunski, J B" sort="Brunski, J B" uniqKey="Brunski J" first="J B" last="Brunski">J B Brunski</name><name sortKey="Helms, J A" sort="Helms, J A" uniqKey="Helms J" first="J A" last="Helms">J A Helms</name><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D J" last="Hunter">D J Hunter</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Mouraret, S" sort="Mouraret, S" uniqKey="Mouraret S" first="S" last="Mouraret">S. Mouraret</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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